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Sustained, significant increase in water consumption or urination
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Sudden weight loss or gain
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Significant decrease in appetite or failure to eat for more than 2 days
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Significant increase in appetite
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Repeated vomiting
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Diarrhea lasting over three days
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Difficulty in passing stool or urine
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Change in housebreaking
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Lameness lasting more that five days or lameness in more than one leg
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Noticeable decrease in vision
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Open sores or scabs on the skin that persist for more than one week
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Foul mouth odor or drooling that lasts for more than two days
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Increasing size of the abdomen
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Increasing inactivity or amount of time spent sleeping
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Hair loss, especially if accompanied by scratching or if in specific areas (as opposed to generalized)
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Excessive panting
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Inability to chew dry food
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Blood in stool or urine
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Sudden collapse or bout or weakness
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A seizure (convulsion)
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Persistent coughing or gagging
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Breathing heavily or rapidly at rest